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AAV vectors

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AAV-PHP capsids

Capsid Characteristics Production efficiency Reference
AAV-PHP.B  Broad and efficient CNS transduction Good  Deverman et. al., Nature Biotechnol 2016
AAV-PHP.B2 Broad and efficient CNS transduction Good  Deverman et. al., Nature Biotechnol 2016 
AAV-PHP.B3 Broad and efficient CNS transduction  Good  Deverman et. al., Nature Biotechnol 2016
AAV-PHP.A More selective astrocyte transduction, reduced non-CNS expression Produces poorly and aggregates Deverman et. al., Nature Biotechnol 2016
AAV-PHP.eB An further evolved AAV-PHP.B variant that more efficiently transduces CNS neurons High Chan et. al., Nature Neuroscience 2017
AAV-PHP.S A capsid with tropism for peripheral neurons and cardiac muscle High Chan et. al., Nature Neuroscience 2017

   

AAV genome resources

VAST - for the customizable, multi-color labeling of cells

schematics that provide an overview of how to use VAST

 

Genomes for characterizing vector tropism

AAV-CAG-NLS-GFP

AAV-CAG-XFPs 

AAV-CAG-GFP

AAV-CAG-GFP-2A-ffLUC

Genomes for cell type-restricted transgene expression

AAV-hSyn1-XFPs: mTurquoise2, mNeonGreen, mRuby

AAV-GFAP-mKate2.5

AAV-GFAP-GFP

AAV-MBP-YFP

AAV-mTH-GFP

AAV-PCP2(Ple155)-GFP


 

Request Reagents 

CLOVER Center-Gradinaru Lab plasmids and viruses available through Addgene (coming soon)